Molecular and Cellular Mechanisms in Depression
نویسندگان
چکیده
Over the past three decades, considerable progress has been made in our understanding of the biology of depressive disorders. Still, there are a great number of unanswered questions regarding the relative roles specific biological systems may play in pathogenesis. This debate in part reflects a number of methodologic factors: a possibly over broad definition of the clinical syndrome of major depression; limitations inherent in studies using indirect measurement of brain neuronal activity; problems inherent in postmortem studies; and an overemphasis on cross-sectional rather than longitudinal studies. In this chapter, we review the current status of the neurochemical and cellular features of depressive disorders.
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